Sometimes switching within the same class of drugs can make a huge difference. The antidepressants most likely to cause weight gain include amitriptyline (Brand name Elavil), mirtazapine (Remeron), paroxetine (Paxil, Brisdelle, Pexeva), escitalopram (Lexapro), sertraline. National Center for Biotechnology Information. Answer (1 of 5) Context I&x27;m a final year pharmacy student with personal experience of mirtazapine. I guess I should also say uh, this isn&x27;t professional or medical advice, it&x27;s just me saying some words. First, a minor side note the higher dose of mirtazapine you take, the less sedative it is. You most likely will get intense hunger for the wrong foods, and with that comes weight gain, dry mouth and constipation caused by what you eat and not Remeron itself. Then you want to sleep a lot. FDA appove of Remeron is for major depressive disorder. Off label use of Remeron PanicAnxiety. Bipolar Depression. Table 3 Guidelines for switching between specific antidepressants Taper means gradual dose reduction, with lowering by increments every few days, usually over a period of 4 weeks, modified by patient experience, drug, illness and other factors. All switches from one antidepressant to another may result in serious complications. Aug 14, 2017 Turns out SDS is incredibly common and can cause a mish-mash of symptoms to make you miserable flu-like dizziness, nausea, fatigue, chills, headaches, insomnia, nightmares, and brain zaps .. T ricyclic antidepressants and more recent antidepressants are generally considered to have equivalent efficacy in the treatment of depression. After a previous report of a marked difference in the response to mirtazapine compared to imipramine, we report here an analysis of different symptom clusters. One hundred seven consecutive in-patients. weight gain. Although less common, the following side effects may also occur difficulty sleeping. difficulty paying attention. blurred vision. acute angle glaucoma, an eye condition. tremors. You made me more curious about Amitriptyline. It seems to be a "mild" drug. Of all the drugs I have taken (Mirtazapine, Prozac, Citalopram, Escitalopram, Zyprexa, Pregabalin, Xanax, Klonopin), Amitriptyline is the only one that has no negative effect in my mood or mind. Are you 16 years away from Chlordiazepoxide. Hi, can you take 15mg of Mirt & 25mg of Amitriptyline together I am finding Mirt is helping me with sleep & appetite but not yet for Depression & Anxiety (have been on Mirt for nearly 3 weeks). Have heard Armitriptyline is better for anxiety which is my main problem, rather than Depression. Thanks.. Take mirtazapine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. To take a mirtazapine disintegrating tablet, open the blister pack with dry hands and place the tablet on your tongue. The tablet will disintegrate on the tongue and can be swallowed with saliva. Switching Patients to or from a Monoamine Oxidase Inhibitor 5.11 Hyponatremia Antidepressant 5.12 Transaminase Elevations 2.5 . Dosage Modifications Due to Drug Interactions 5.13 Discontinuation Syndrome 2.6 . Discontinuation of REMERONREMERONSolTab Treatment 5.14 Use in Patients with Concomitant Illness. Search within rAmitriptyline. rAmitriptyline. Log In Sign Up. User account menu. Found the internet 2. Close. 2. Posted by 5 months ago. Switching from Mirtazapine to Ami. Hey there, So I was just diagnosed with FD (Functional Dyspepsia) and my GI prescribed me Ami to help with my vagus nerve. Im hopeful, but Im worried how this. SSRI with mirtazapine or mianserin. This is one of the most popular combinations and has been proposed on various grounds rapid onset of effect is possible, owing to the receptor profile of noradrenergic and specific serotonergic antidepressants (NaSSAs) (see below); side-effects of the SSRI may be nullified by the NaSSA and vice versa;. Some evidence for SSRIs plus mirtazapine and for venlafaxine plus mirtazapine. Caution re serotonin syndrome. Psychotic Depression When switching be aware of interactions between antidepressants and the risk of serotonin syndrome or or Choice of treatments in refractory depression. To be considered if standard treatment has failed. Mirtazapine has an average rating of 6.8 out of 10 from a total of 1809 ratings on Drugs.com. 55 of reviewers reported a positive effect, while 22 reported a negative effect. Zoloft has an average rating of 7.2 out of 10 from a total of 1714 ratings on Drugs.com. 63 of reviewers reported a positive effect, while 19 reported a negative effect. A switch in mood to an unusual state of excitement, irritability or happiness Skin rash, itchy skin or hives Thoughts of self harm, hostility or suicide . Mirtazapine can make some individuals experience these temporary side effects. Mirtazapine may increase the effects of alcohol, resulting in more sedation or dizziness. Mirtazapine vs. Amitriptyline (Weight Gain) Discussion in 'Support' started by Christian82, Oct 5, 2016. Search. Search titles only; Posted by Member Separate names with a comma. I was just wondering if there is anyone that made the switch and if they benefit from it. Cheers, Chris Christian82, Oct 5, 2016 1. gotyoubynuts Member. Tinnitus. AUC of amitriptyline were decreased in female volunteers (23 and Efficacy and dosing After 6 weeks of treatment with mean dose of 13, respectively) after co-administration of mirtazapine, while C,,, 30 mgday of mirtazapine, 72 of patients were classified as CGI was increased in males (23). Switch medication from mirtazapine to amitriptyline . Before day 1 Gradually reduce dosage of mirtazapine to a maximum of 30 mgday, when this dosage is > 30 mgday. Day 1 Reduce dosage of mirtazapine to 15 mgday. Day 8 Stop administration of mirtazapine. Day 2 Start with normal dosage and increase with about 25 (up to 50) every 3 days .. Hi Selah, Yes, amitriptyline can cause tinnitus in some people. I am one of those. I have been on 25mg amitriptyline for many years for pain and developed a mild tinnitus. I did not even connect the tinnitus with amitriptyline because it did not bother me to function properly (Work, sleep, docial life). Such switching of mood into mania, a mixed-state, or psychosis can be dangerous. This switching is particularly prevalent among juveniles and young adults exposed to treatment with an antidepressant or stimulant for a depressive, anxiety, or attention disorder. 1 Such pathological shifts of mood and behavior may represent adverse drug. I take the 20mg fluoxetine at 6am when I wake up ,I take the 10mg amitriptyline at 7pm and the 15 mirtazapine at 10pm just before sleep.I have no bad side effects it's just I read online that it could be a bad combo but my doctor said it's OK but I wanted a second opinion as there is to much conflicting info online. When the initial antidepressants were switched to non-SSRI agents, venlafaxine (21.2) was most commonly chosen among newer dual-action antidepressants, followed by mirtazapine (6.1), bupropion (6.1); switching to other antidepressants comprised only 9 of overall switching to non-SSRIs (milnacipran, 3; imipramine, 3; and amitriptyline, 3). weight gain. dizziness, and. nausea. Tell your doctor if you experience serious side effects of Remeron including agitation, hallucinations, fever, fast or uneven heart rate, loss of coordination or feeling unsteady, stiff muscles, confusion, tremors, flu symptoms, memory problems, weakness, overactive reflexes, nausea, vomiting, diarrhea, loss. Remeron (mirtazapine) Trintellix (vortioxetine) Those that made the least-effective list of antidepressant drugs sold in the United States included Luvox (fluvoxamine) Oleptro (trazodone) . In addition, Catanzaro noted that while amitriptyline was on the most-effective list, it was also on the least-tolerated list, and he said it&x27;s generally. In US controlled studies, somnolence was reported in 54 of patients treated with mirtazapine tablets, compared to 18 for placebo and 60 for amitriptyline. In these studies, somnolence resulted in discontinuation for 10.4 of mirtazapine-treated patients, compared to 2.2 for placebo. Amitriptyline And Weight Gain. As mentioned above, the use of antidepressants such as Elavil could be related to gaining some weight.In fact, studies report that this is one of the most frequent untoward Amitriptyline adverse effects, and one of the reasons for non-adherence to antidepressants. Several theories suggest a link between an increase in weight and Elavil use. The safety and efficacy of amitriptyline for the treatment of depression have not been established in children less than 12 years of age. In a pooled analysis of placebo-controlled trials of antidepressants (n 4,500 pediatrics and 77,000 adults), there was an increased risk for suicidal thoughts and behaviors in patients 24 years of age and younger receiving an antidepressant versus placebo. If youve been diagnosed with depression, your doctor will likely start you on a treatment plan of antidepressants like a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI). Reduce SSRI gradually and stop. Leave 2 to 3 days then start low dose TCA.Reduce venlafaxine dose and cross-taper cautiously.Reduce mirtazapine. Aug 16, 2018 No direct answer These are 2 different drugs. Again, there is "no better than" or "as good as". Treatment of any disorder should be individualized. I would think that Remeron (mirtazapine) is more often prescribed for sleep disorders where as Amitriptyline is more often prescribed for pain when talking about these 2 conditions specifically.. Antiepileptics mirtazapine can reduce the seizure threshold, and carbamazepine, phenobarbital and phenytoin decrease mirtazapine levels.; Chlorpromazine increased risk of agranulocytosis.Monitor for blood dyscrasias. Monoamine oxidase inhibitors (MAOIs) increased risk of developing serotonin syndrome. Avoid concurrent use (and for 2 weeks after. Remeron (mirtazapine) usually stays in the body anywhere between four and eight days, depending on the individual&x27;s health and dosage amount. Mirtazapine has a half-life of 20 to 40 hours, so most of the drug is out of the body within four days after the last dose. Mirtazapine is metabolized by the liver, and most of it is eliminated through.